The ins and outs of iron homeostasis

Physiology (Bethesda). 2006 Apr:21:115-23. doi: 10.1152/physiol.00052.2005.

Abstract

Iron is an essential element that is toxic when it accumulates in excess. Intricate regulatory mechanisms have evolved to maintain iron homeostasis within cells and between different tissues of complex organisms. This review discusses the proteins involved in iron transport and storage and their regulation in health and disease.

Publication types

  • Review

MeSH terms

  • Animals
  • Antimicrobial Cationic Peptides / physiology
  • Cation Transport Proteins / physiology
  • Hepcidins
  • Homeostasis / physiology*
  • Humans
  • Intestinal Mucosa / metabolism
  • Iron / metabolism*
  • Iron Metabolism Disorders / etiology
  • Iron Metabolism Disorders / physiopathology
  • Iron Overload / etiology
  • Iron Overload / physiopathology
  • Iron-Regulatory Proteins / physiology

Substances

  • Antimicrobial Cationic Peptides
  • Cation Transport Proteins
  • Hepcidins
  • Iron-Regulatory Proteins
  • metal transporting protein 1
  • Iron