Characteristics of scratching behavior induced by some chemical mediators in hairless mice

J Pharmacol Sci. 2006 Apr;100(4):285-8. doi: 10.1254/jphs.fpj06002x. Epub 2006 Mar 25.


To find the characteristics of scratching behavior in hairless mice (HR-1), compound 48/80 and some putative chemical mediators of allergic reaction were injected intradermally into the backs of mice, and the number of scratching behaviors was measured. As reference mice, NC/Nga, ICR, and ddY mice were used. Scratching behavior in HR-1 and ICR mice was increased dose-dependently by compound 48/80. The same result was also observed with NC/Nga and ddY mice. However, the response in NC/Nga and ddY mice was far less than those of HR-1 and ICR mice. Similar to NC/Nga and ddY mice, HR-1 mice showed less sensitivity to histamine than ICR mice. On the other hand, the HR-1 mice showed a high response to serotonin compared with those of the NC/Nga and ddY mice. The scratching behavior in HR-1 mice induced by substance P was increased, but the effect was less potent than those in NC/Nga, ICR, and ddY mice. These results suggest that the scratching behavior induced by compound 48/80 in HR-1 mice is mainly attributable to serotonin.

MeSH terms

  • Animals
  • Antipruritics / pharmacology
  • Behavior, Animal / drug effects*
  • Dermatitis, Atopic / chemically induced
  • Dermatitis, Atopic / prevention & control
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Female
  • Histamine / toxicity
  • Methysergide / pharmacology
  • Mice
  • Mice, Hairless
  • Mice, Inbred ICR
  • Pruritus / chemically induced*
  • Pruritus / prevention & control
  • Serotonin / toxicity
  • Serotonin Antagonists / pharmacology
  • Species Specificity
  • p-Methoxy-N-methylphenethylamine / antagonists & inhibitors
  • p-Methoxy-N-methylphenethylamine / toxicity*


  • Antipruritics
  • Serotonin Antagonists
  • Serotonin
  • p-Methoxy-N-methylphenethylamine
  • Histamine
  • Methysergide