The ubiquitin pathway for protein degradation

Trends Biochem Sci. 1991 Jul;16(7):265-8. doi: 10.1016/0968-0004(91)90101-z.


Cellular proteins are marked for selective degradation by their ligation to the polypeptide ubiquitin. Recent studies have revealed information on the mechanisms involved in the selection of proteins for ligation to ubiquitin and on the mode of degradation of ubiquitinated proteins. Much remains to be learned about the high selectivity of this degradation pathway. Recent evidence that the cell-cycle regulatory proteins, cyclins, are degraded by the ubiquitin pathway points the way to future challenges in ubiquitin research.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Cycle
  • Cyclins / metabolism
  • Ligases / metabolism*
  • Ubiquitin-Protein Ligases
  • Ubiquitins / metabolism*


  • Cyclins
  • Ubiquitins
  • Ubiquitin-Protein Ligases
  • Ligases