[Investigation of antioxidant activity of quinoline thioderivatives]

Ukr Biokhim Zh (1999). May-Jun 2005;77(3):87-95.
[Article in Ukrainian]

Abstract

Antioxidant activity of new synthetic physiologically active substances (thioderivatives of quinoline) are investigated using the complex of primary estimation techniques in vitro and in vivo. It is shown that the compounds investigated display both antiradical and anti-oxidative activity, most strongly delineated for the compounds with methoxygroup in the 6th position of quinoline cycle. The suppositions concerning the mechanism of their antioxidant activity are made.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Antioxidants / chemistry
  • Antioxidants / pharmacology*
  • Brain Ischemia / metabolism
  • Epinephrine / chemistry
  • Free Radicals / chemistry*
  • Models, Biological
  • Molecular Structure
  • Oxidation-Reduction
  • Oxidative Stress / drug effects*
  • Quinolines / chemistry
  • Quinolines / pharmacology*
  • Rats
  • Rats, Wistar
  • Sulfur Compounds / chemistry
  • Sulfur Compounds / pharmacology*

Substances

  • Antioxidants
  • Free Radicals
  • Quinolines
  • Sulfur Compounds
  • Epinephrine