Cytokine and anti-cytokine therapy for asthma

Curr Allergy Asthma Rep. 2006 Mar;6(2):117-21. doi: 10.1007/s11882-006-0049-9.

Abstract

Cytokines play a critical role in the pathogenesis of asthma. Asthma resolution may depend on the correction of dysregulated cytokine expression, which is a characteristic feature of this chronic inflammatory disease. It is, therefore, not surprising that attempts have been made to either block cytokines present at elevated levels or to substitute cytokines that are insufficiently expressed in asthma. In this article, the results of these studies are discussed, and the obtained insights regarding asthma pathogenesis and new treatment options are summarized.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Anti-Asthmatic Agents / therapeutic use*
  • Antibodies / therapeutic use
  • Asthma / drug therapy*
  • Asthma / metabolism
  • Cytokines / antagonists & inhibitors*
  • Cytokines / immunology
  • Cytokines / metabolism*
  • Humans
  • Inflammation Mediators / antagonists & inhibitors
  • Interferons / antagonists & inhibitors
  • Interferons / immunology
  • Interleukins / antagonists & inhibitors
  • Interleukins / immunology

Substances

  • Anti-Asthmatic Agents
  • Antibodies
  • Cytokines
  • Inflammation Mediators
  • Interleukins
  • Interferons