Suspected clopidogrel resistance in a patient with acute stent thrombosis

Nat Clin Pract Cardiovasc Med. 2006 Apr;3(4):226-30; quiz 232. doi: 10.1038/ncpcardio0517.


Background: A 67-year-old man with supraventricular tachycardia associated with angina underwent coronary angiographic assessment. This investigation revealed mild coronary artery disease in his left main coronary artery and significant stenosis of the ramus medianus (left intermediate artery). A drug-eluting stent was deployed and treatment with clopidogrel and eptifibatide started. The patient subsequently developed chest pain accompanied by hypotension, hypoxemia and electrocardiographic changes that indicated acute myocardial infarction. Emergency angiography revealed occlusion of the ramus medianus despite clopidogrel therapy.

Investigations: Coronary angiography, hypercoagulable work up and platelet function tests.

Diagnosis: Acute stent thrombosis and suspected clopidogrel resistance, culminating in ST-segment elevation myocardial infarction after percutaneous coronary intervention.

Management: Warfarin, aspirin and clopidogrel drug therapy.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Angioplasty, Balloon, Coronary / instrumentation*
  • Angioplasty, Balloon, Coronary / methods
  • Clopidogrel
  • Coronary Angiography
  • Coronary Stenosis / diagnostic imaging
  • Coronary Stenosis / therapy
  • Coronary Thrombosis / diagnostic imaging*
  • Coronary Thrombosis / therapy*
  • Drug Delivery Systems
  • Drug Resistance
  • Fibrinolytic Agents
  • Follow-Up Studies
  • Humans
  • Male
  • Prosthesis Failure
  • Recurrence
  • Risk Assessment
  • Stents / adverse effects*
  • Ticlopidine / administration & dosage
  • Ticlopidine / analogs & derivatives*
  • Treatment Outcome


  • Fibrinolytic Agents
  • Clopidogrel
  • Ticlopidine