Posttraumatic thromboprophylaxis revisited: an argument against the current methods of DVT and PE prophylaxis after injury

World J Surg. 2006 Apr;30(4):483-7. doi: 10.1007/s00268-005-0427-9.


Background: Thromboprophylaxis after injury is a controversial issue. Practices and outcomes vary widely.

Methods: Review of selected trauma literature on venous thromboprophylaxis after injury.

Results: Multiple trauma articles suggest that the efficacy of different methods of thromboprophylaxis is unproven. Most of the practices on this issue are extrapolated from studies which were performed in non-trauma patients and therefore, may not be applicable in the unique trauma population.

Conclusions: In the absence of undisputable evidence, none of the current methods of venous thromboprophylaxis after injury should be considered as standard of care. There is a need to discover new methods of thromboprophylaxis for the Trauma patient.

Publication types

  • Comparative Study
  • Editorial

MeSH terms

  • Anticoagulants / administration & dosage
  • Anticoagulants / adverse effects
  • Clinical Trials as Topic
  • Heparin / administration & dosage
  • Heparin / adverse effects
  • Heparin, Low-Molecular-Weight / administration & dosage
  • Heparin, Low-Molecular-Weight / adverse effects
  • Humans
  • Intermittent Pneumatic Compression Devices
  • Pulmonary Embolism / blood
  • Pulmonary Embolism / prevention & control*
  • Vena Cava Filters
  • Venous Thrombosis / blood
  • Venous Thrombosis / prevention & control*
  • Wounds and Injuries / blood
  • Wounds and Injuries / complications*
  • Wounds and Injuries / surgery


  • Anticoagulants
  • Heparin, Low-Molecular-Weight
  • Heparin