Eukaryotic evolution, changes and challenges

Nature. 2006 Mar 30;440(7084):623-30. doi: 10.1038/nature04546.


The idea that some eukaryotes primitively lacked mitochondria and were true intermediates in the prokaryote-to-eukaryote transition was an exciting prospect. It spawned major advances in understanding anaerobic and parasitic eukaryotes and those with previously overlooked mitochondria. But the evolutionary gap between prokaryotes and eukaryotes is now deeper, and the nature of the host that acquired the mitochondrion more obscure, than ever before.

Publication types

  • Review

MeSH terms

  • Biological Evolution*
  • Eukaryotic Cells / cytology*
  • Eukaryotic Cells / metabolism
  • Hydrogen / metabolism
  • Mitochondria / metabolism
  • Phylogeny
  • Prokaryotic Cells / cytology
  • Prokaryotic Cells / metabolism


  • Hydrogen