The biosynthesis, molecular genetics and enzymology of the polyketide-derived metabolites

Nat Prod Rep. 2006 Apr;23(2):256-320. doi: 10.1039/b301028g. Epub 2005 Dec 19.

Abstract

This review covers the biosynthesis of aliphatic and aromatic polyketides as well as mixed polyketide/NRPS metabolites, and discusses the molecular genetics and enzymology of the proteins responsible for their formation.

Publication types

  • Review

MeSH terms

  • Macrolides* / chemistry
  • Macrolides* / metabolism
  • Macrolides* / pharmacology
  • Molecular Structure
  • Polyketide Synthases* / genetics
  • Polyketide Synthases* / metabolism

Substances

  • Macrolides
  • Polyketide Synthases