Assessment of serum cystatin C in children with congenital solitary kidney

Pediatr Nephrol. 2006 May;21(5):688-93. doi: 10.1007/s00467-006-0065-y. Epub 2006 Mar 30.


The aim of the study was to assess serum cystatin C level in children with a congenital solitary kidney, depending on their age and compensatory overgrowth of the kidney. The study group (I) consisted of 36 children, 3-21 years of age (median 10.8 years), with a congenital solitary kidney and no other urinary defects. The control group (C) contained 36 healthy children, 5-21 years old (median 10.9 years). Nephelometric methods were used to determine serum cystatin C level, the Jaffe method to assess creatinine concentration and the Schwartz formula to estimate glomerular filtration rate. Kidney length was measured with the patient in a supine position, and overgrowth was estimated (O%) in comparison with the respective kidney in the control group. Serum cystatin C level in group I was higher than that in the control group (P<0.05). Increased values, above 0.95 mg/l, were found in 16/36 (44%) children aged 12-21 years. Glomerular filtration rate (GFR, estimated by the Schwartz formula) and creatinine level in group I were similar to those of the control group (P>0.05). Increased kidney length was found (median 18.2%). Cystatin C concentration was positively correlated with O% (r=0.406, P<0.01) and kidney length to child height ratio (L/H) (r=0.376, P<0.05). We conclude that Increased serum cystatin C concentration in patients with a unilateral congenital solitary kidney occurs after 12 years of age and correlates with compensatory overgrowth of the kidney.

MeSH terms

  • Adaptation, Physiological / physiology
  • Adolescent
  • Adult
  • Age Factors
  • Child
  • Child, Preschool
  • Creatinine / blood
  • Cystatin C
  • Cystatins / blood*
  • Female
  • Glomerular Filtration Rate
  • Humans
  • Kidney / abnormalities*
  • Kidney / growth & development
  • Male
  • Organ Size / physiology
  • Urogenital Abnormalities / blood
  • Urogenital Abnormalities / physiopathology*


  • CST3 protein, human
  • Cystatin C
  • Cystatins
  • Creatinine