Malignancies in children with human immunodeficiency virus type 1 infection. The Italian Multicenter Study on Human Immunodeficiency Virus Infection in Children

Cancer. 1991 Dec 1;68(11):2473-7. doi: 10.1002/1097-0142(19911201)68:11<2473::aid-cncr2820681125>;2-l.


Cancer has been closely associated with human immunodeficiency virus (HIV) infection but this is less frequent in children. Non-Hodgkin's lymphomas represent the most frequently reported single tumor. The authors report seven cases of malignant tumors resulting from the analysis of all (n = 1321) children enrolled in the Italian Register for HIV Infection in Children. Tumors were distributed as follows: non-Hodgkin's B-cell lymphoma (four cases); and Kaposi's sarcoma, hepatoblastoma, acute B-cell lymphoblastic leukemia (one case each). Hepatoblastoma had never been previously reported in HIV-infected children. Also in the current series, non-Hodgkin's B-cell lymphoma is the most frequent single tumor. Five of the seven cancers belonged to the B-cell line. All but one of the seven children have died. Specific chemotherapy was provided in three cases, with some clinical improvement. The treatment of malignancies in HIV-infected children is hampered by increased risk of opportunistic infections often fatal even in children with apparent remission from the tumor.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Burkitt Lymphoma / etiology
  • Carcinoma, Hepatocellular / etiology
  • Child
  • Child, Preschool
  • Female
  • HIV Infections / complications*
  • HIV-1*
  • Humans
  • Infant
  • Liver Neoplasms / etiology
  • Lymphoma, AIDS-Related / etiology
  • Male
  • Neoplasms / etiology*
  • Sarcoma, Kaposi / etiology