Multiple functions of Notch signaling in self-renewing organs and cancer

FEBS Lett. 2006 May 22;580(12):2860-8. doi: 10.1016/j.febslet.2006.03.024. Epub 2006 Mar 20.


In recent years a substantial body of evidence has accumulated to support the notion that signaling pathways known to be important during embryonic development play important roles in regulating self-renewing tissues. Moreover, the same pathways are often deregulated during tumorigenesis due to mutations of key elements of these pathways. The Notch signaling cascade meets all of the above-mentioned criteria. We discuss here the pleiotropic roles of the Notch signaling pathway in three different self-renewing organs (intestine, hematopoietic system and skin) and how its deregulation is involved in tumorigenesis.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Hematopoiesis
  • Humans
  • Intestines / cytology
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Receptors, Notch / metabolism*
  • Signal Transduction*


  • Receptors, Notch