Facilitation of Glutamatergic Synaptic Transmission in Hippocampal CA1 Area of Rats With Traumatic Brain Injury

Neurosci Lett. 2006 Jun 19;401(1-2):136-41. doi: 10.1016/j.neulet.2006.03.005. Epub 2006 Mar 29.

Abstract

We investigated the effects of traumatic brain injury (TBI) on the glutamatergic synaptic transmission in the hippocampal CA1 area. A moderate impact (3.8-4.8atm) was applied onto the left parietal cerebral cortex by a fluid percussion injury (FPI) device. Conventional intracellular recordings were made from hippocampal CA1 pyramidal neurons in vitro. Electrophysiological properties of these neurons were compared between three groups (control, FPI-ipsilateral, and FPI-contralateral). The excitability of postsynaptic membrane of CA1 pyramidal neurons was not altered by the moderate FPI; however, the evoked glutamatergic excitatory synaptic transmission in the pyramidal neurons of post-FPI-CA1 was enhanced. Paired-pulse facilitation (PPF) was significantly suppressed in both the FPI-ipsilateral and FPI-contralateral groups and the frequencies of mEPSPs in neurons from the bilateral FPI groups were greater than the frequency in the control group. These results suggest that the glutamatergic synaptic transmission in the hipppocampal CA1 area is facilitated through presynaptic mechanisms after TBI.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / physiology
  • Animals
  • Brain Injuries / complications
  • Brain Injuries / metabolism*
  • Brain Injuries / physiopathology
  • Disease Models, Animal
  • Epilepsy / etiology
  • Epilepsy / metabolism*
  • Epilepsy / physiopathology
  • Excitatory Postsynaptic Potentials / physiology
  • Glutamic Acid / metabolism*
  • Hippocampus / metabolism*
  • Hippocampus / physiopathology
  • Male
  • Neuronal Plasticity / physiology
  • Presynaptic Terminals / metabolism*
  • Pyramidal Cells / metabolism
  • Rats
  • Rats, Wistar
  • Synaptic Transmission / physiology*

Substances

  • Glutamic Acid