Use of intravenous immunoglobulin in human disease: a review of evidence by members of the Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology

Jordan S Orange; Elham M Hossny; Catherine R Weiler; Mark Ballow; Melvin Berger; Francisco A Bonilla; Rebecca Buckley; Javier Chinen; Yehia El-Gamal; Bruce D Mazer; Robert P Nelson Jr; Dhavalkumar D Patel; Elizabeth Secord; Ricardo U Sorensen; Richard L Wasserman; Charlotte Cunningham-Rundles; Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology

doi:10.1016/j.jaci.2006.01.015

Use of intravenous immunoglobulin in human disease: a review of evidence by members of the Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology

J Allergy Clin Immunol. 2006 Apr;117(4 Suppl):S525-53. doi: 10.1016/j.jaci.2006.01.015.

Authors

Jordan S Orange¹, Elham M Hossny, Catherine R Weiler, Mark Ballow, Melvin Berger, Francisco A Bonilla, Rebecca Buckley, Javier Chinen, Yehia El-Gamal, Bruce D Mazer, Robert P Nelson Jr, Dhavalkumar D Patel, Elizabeth Secord, Ricardo U Sorensen, Richard L Wasserman, Charlotte Cunningham-Rundles; Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology

Affiliation

¹ Department of Pediatrics, University of Pennsylvania School of Medicine, The Children's Hospital of Philadelphia, Philadelphia 19104, USA. Orange@mail.med.upenn.edu

PMID: 16580469
DOI: 10.1016/j.jaci.2006.01.015

Abstract

Human immunoglobulin prepared for intravenous administration (IGIV) has a number of important uses in the treatment of disease. Some of these are in diseases for which acceptable treatment alternatives do not exist. In this review we have evaluated the evidence underlying a wide variety of IGIV uses and make specific recommendations on the basis of these data. Given the potential risks and inherent scarcity of IGIV, careful consideration of the indications for and administration of IGIV is warranted.

Publication types

Review

MeSH terms

Asthma / therapy
Autoimmune Diseases / therapy
Clinical Trials as Topic
Communicable Diseases / therapy
Cytomegalovirus Infections / etiology
Cytomegalovirus Infections / therapy
Graft Rejection / therapy
Humans
Immunization, Passive*
Immunoglobulins, Intravenous / administration & dosage
Immunoglobulins, Intravenous / adverse effects
Immunoglobulins, Intravenous / therapeutic use*
Immunologic Deficiency Syndromes / therapy
Kidney Transplantation / adverse effects
Mental Disorders / therapy
Nervous System Diseases / therapy
Respiratory Syncytial Virus Infections / etiology
Respiratory Syncytial Virus Infections / therapy
Risk
Skin Diseases / therapy

Substances

Immunoglobulins, Intravenous