Induction of an endothelial cell growth factor by human cytomegalovirus infection of fibroblasts

J Gen Virol. 1991 Nov;72 ( Pt 11):2765-70. doi: 10.1099/0022-1317-72-11-2765.

Abstract

Human cytomegalovirus (HCMV) induction of growth factors in fibroblasts was investigated after establishing serum-free culture conditions conducive to viral replication. HCMV infection induced a type II heparin-binding growth factor which stimulated human endothelial cell proliferation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Division
  • Cytomegalovirus / physiology*
  • Endothelium, Vascular / cytology
  • Fibroblast Growth Factor 2 / biosynthesis*
  • Fibroblasts / metabolism
  • Fibroblasts / microbiology
  • Heparin / pharmacology
  • Humans
  • Insulin / pharmacology
  • Thymidine / metabolism
  • Transferrin / pharmacology
  • Virus Replication

Substances

  • Insulin
  • Transferrin
  • Fibroblast Growth Factor 2
  • Heparin
  • Thymidine