Cyclin e overexpression reduces infiltrative growth in breast cancer: yet another link between proliferation control and tumor invasion

Cell Cycle. 2006 Mar;5(6):606-9. doi: 10.4161/cc.5.6.2569. Epub 2006 Mar 15.


Overexpression of cyclin E is strongly linked to an aggressive phenotype and poor prognosis in breast cancer. Unexpectedly, it has been shown that cyclin E overexpression decreases mobility and invasiveness of breast cancer cells. In fact, in a study of 985 breast cancers, cyclin E correlated with less infiltrative growth. This suggests a novel function for cyclin E in breast cancer tumorigenesis and a mutual control of proliferation and invasive behavior.

Publication types

  • Review

MeSH terms

  • Animals
  • Breast Neoplasms / genetics*
  • Cell Cycle Proteins / genetics
  • Cell Proliferation*
  • Cell Transformation, Neoplastic / genetics
  • Cyclin E / genetics*
  • Gene Expression Regulation, Neoplastic / genetics*
  • Genes, cdc / physiology
  • Humans
  • Neoplasm Invasiveness / genetics*


  • Cell Cycle Proteins
  • Cyclin E