Endoscopic endonasal approaches for repair of cerebrospinal fluid leaks: nine-year experience

Neurosurgery. 2006 Apr;58(4 Suppl 2):ONS-246-56; discussiom ONS-256-7. doi: 10.1227/01.NEU.0000193924.65297.3F.


Objective: To describe surgical endoscopic experience in the repair of cerebrospinal fluid leaks treated by transnasal approaches.

Methods: Different surgical approaches and techniques in the repair of cranial base defects are reviewed in a series of 135 patients.

Results: Success rate at first attempt was 93.3%. Only 9 patients (6.7%) needed a second surgical repair, and in one patient, a coronal approach with frontal craniotomy was necessary. In the other eight cases, an endoscopic procedure was chosen. Two patients needed a third endonasal endoscopic surgical repair, with successful outcome.

Conclusion: The target of endoscopic endonasal technique in the repair of cerebrospinal fluid leaks is to ensure a stable duraplasty with the least invasive approach avoiding craniotomy. A correct diagnosis surely allows the choice of the best treatment, surgical approach, graft, and technique. Our multidisciplinary approach to this pathology during these years has been essential to gain our challenging results.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Cerebrospinal Fluid Rhinorrhea / etiology
  • Cerebrospinal Fluid Rhinorrhea / pathology
  • Cerebrospinal Fluid Rhinorrhea / surgery*
  • Child
  • Child, Preschool
  • Decision Trees
  • Endoscopy / methods*
  • Female
  • Follow-Up Studies
  • Humans
  • Infant
  • Magnetic Resonance Imaging / methods
  • Male
  • Medical Illustration
  • Middle Aged
  • Nose / pathology
  • Nose / surgery*
  • Otorhinolaryngologic Surgical Procedures / methods*
  • Postoperative Care
  • Prostheses and Implants
  • Retrospective Studies
  • Skull Base / surgery
  • Sphenoid Sinus / pathology
  • Sphenoid Sinus / surgery*
  • Tomography, X-Ray Computed / methods
  • Treatment Outcome