Comparative Study
doi: 10.1038/nn1678.
Epub 2006 Apr 2.
Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation
Affiliations
- PMID: 16582904
- DOI: 10.1038/nn1678
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Comparative Study
Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation
Nat Neurosci.
2006 May.
Abstract
Postnatal glutamatergic principal neuron synapses are typically presumed to express only calcium-impermeable (CI), GluR2-containing AMPARs under physiological conditions. Here, however, we demonstrate that long-term potentiation (LTP) in CA1 hippocampal pyramidal neurons causes rapid incorporation of GluR2-lacking calcium-permeable (CP)-AMPARs: CP-AMPARs are present transiently, being replaced by GluR2-containing AMPARs approximately 25 min after LTP induction. Thus, CP-AMPARs are physiologically expressed at CA1 pyramidal cell synapses during LTP, and may be required for LTP consolidation.
Comment in
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LTP: AMPA receptors trading places.Nat Neurosci. 2006 May;9(5):593-4. doi: 10.1038/nn0506-593. Nat Neurosci. 2006. PMID: 16639403 No abstract available.
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