Weight gain associated with the alpha2a-adrenergic receptor -1,291 C/G polymorphism and olanzapine treatment

Am J Med Genet B Neuropsychiatr Genet. 2006 Jun 5;141B(4):394-7. doi: 10.1002/ajmg.b.30311.

Abstract

Weight gain can be an adverse effect of antipsychotics and is an important factor for long-term health and treatment compliance. Many reports have shown that the alpha(2)-adrenergic receptor may be related to eating behaviors or lipolytic activities, both associated with body weight change. We hypothesized that there might be a relationship between the alpha(2a)-adrenergic receptor -1,291 C/G polymorphism and olanzapine-induced weight gain. A group of 62 Korean schizophrenic patients participated in a study; weight and height measurements were obtained prior to starting olanzapine and measured again after long-term treatment. Genotyping for the -1291 C/G polymorphism was performed on all participants. Body weight changes from baseline to endpoint were significantly associated with genotypes (P = 0.028). The frequency of the G allele was significantly higher in subjects who had severe weight gain (defined as a more than 10% weight gain from baseline) compared to subjects who did not have extreme weight gain (less than 10% weight gain from baseline) (X(2) = 6.120, P = 0.013; OR = 2.58, 95% CI = 1.21-5.51). Therefore, the findings from this study support a relationship between the -1291 C/G polymorphism of the alpha(2a)-adrenergic receptor and weight gain in Korean schizophrenic patients receiving olanzapine treatment.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Alleles
  • Antipsychotic Agents / adverse effects
  • Antipsychotic Agents / therapeutic use
  • Benzodiazepines / adverse effects
  • Benzodiazepines / therapeutic use
  • Body Mass Index
  • Female
  • Gene Frequency
  • Genotype
  • Humans
  • Korea
  • Male
  • Middle Aged
  • Olanzapine
  • Polymorphism, Single Nucleotide*
  • Receptors, Adrenergic, alpha-2 / genetics*
  • Schizophrenia / drug therapy*
  • Schizophrenia / genetics
  • Schizophrenia / physiopathology
  • Treatment Outcome
  • Weight Gain / drug effects*
  • Weight Gain / genetics

Substances

  • ADRA2A protein, human
  • Antipsychotic Agents
  • Receptors, Adrenergic, alpha-2
  • Benzodiazepines
  • Olanzapine