Bacteriocins Pep5 and epidermin inhibit Staphylococcus epidermidis adhesion to catheters

Curr Microbiol. 2006 May;52(5):350-3. doi: 10.1007/s00284-005-0152-5. Epub 2006 Apr 1.


Pep5 and epidermin bacteriocins were tested on clinical strains of Staphylococcus epidermidis and S. aureus isolated from catheter-related infections. These bacteriocins were inhibitory to several isolates at a concentration of 640 activity units mL(-1). The ability of bacteriocins in inhibiting adhesion of S. epidermidis to silicone catheters was evaluated. When Pep5 and epidermin were added to in vitro catheter colonization experiments, there was a significant decrease in the cell number of S. epidermidis adhered to silicone catheters. Bacteriocins used to decrease bacterial attachment to medical devices may represent a novel strategy to control catheter-related infections.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Adhesion / drug effects*
  • Bacteriocins / pharmacology*
  • Catheters, Indwelling / microbiology*
  • Humans
  • Microbial Sensitivity Tests / methods
  • Peptides / pharmacology*
  • Silicones
  • Staphylococcus epidermidis / drug effects*
  • Staphylococcus epidermidis / physiology


  • Anti-Bacterial Agents
  • Bacteriocins
  • Peptides
  • Silicones
  • epidermin