[Effect of thymagen, thymalin and vilosen on the cAMP and cGMP levels and phosphodiesterase activity in spleen lymphocytes during sensitization and anaphylactic shock]

Ukr Biokhim Zh (1978). 1991 Jul-Aug;63(4):104-6.
[Article in Russian]


It is established that the effect of thymus-derived species is connected with the cyclic nucleotide system. The action of thymus-derived immunocorrectors (thymalin, thymagen, vilosen) on catabolic processes of cyclic nucleotides has been observed under conditions of anaphylaxy and sensibilization. They show that sensibilization of the animal is bound up with a decrease of the cAMP/cGMP ratio. Anaphylaxis induces levelling of the cAMP/cGMP ratio up to the reference level. So, activity of enzymes of cyclic nucleotide catabolism grows due to the influence of thymogen, thymalin and vilosen in lymphocytes of sensibilized guinea pigs and tends to an increase in lymphocytes of anaphylaxis-treated animals.

Publication types

  • English Abstract

MeSH terms

  • Adjuvants, Immunologic / pharmacology
  • Anaphylaxis / metabolism*
  • Animals
  • Cyclic AMP / metabolism
  • Cyclic GMP / metabolism
  • Dipeptides*
  • Guinea Pigs
  • Lymphocytes / drug effects
  • Lymphocytes / metabolism*
  • Peptides / pharmacology*
  • Phosphoric Diester Hydrolases / metabolism
  • Spleen / cytology
  • Spleen / enzymology
  • Spleen / metabolism*
  • Thymus Extracts / pharmacology*
  • Thymus Hormones / pharmacology*


  • Adjuvants, Immunologic
  • Dipeptides
  • Peptides
  • Thymus Extracts
  • Thymus Hormones
  • iilozen
  • thymogen
  • thymalin
  • Cyclic AMP
  • Phosphoric Diester Hydrolases
  • Cyclic GMP