Effect of millimeter waves on cyclophosphamide induced NF-kappaB

Electromagn Biol Med. 2006;25(1):23-7. doi: 10.1080/15368370600572946.

Abstract

Antiapoptotic activity of NF-Kappa B (NF-kappaB) in tumors contributes to acquisition of resistance to chemotherapy. The effect of millimeter waves (MMWs) on NF-kappaB activation induced by cyclophosphamide (CPA) was studied in the spleen of mice. CPA, an anticancer drug, caused a marked increase (58.9-fold) in NF-kappaB DNA-binding activity as compared to the control group. No significant enhancement in NF-kappaB activity (0.51-fold) was observed when the CPA group was also irradiated with MMWs. These results suggest that treatment with MMWs can inhibit activation of NF-kappaB induced by chemotherapeutic drugs.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Antineoplastic Agents, Alkylating / pharmacology
  • Antineoplastic Agents, Alkylating / therapeutic use
  • Cyclophosphamide / pharmacology*
  • Cyclophosphamide / therapeutic use
  • DNA / metabolism
  • DNA / radiation effects*
  • Mice
  • Mice, Inbred BALB C
  • NF-kappa B / antagonists & inhibitors
  • NF-kappa B / metabolism
  • NF-kappa B / radiation effects*
  • Neoplasms / drug therapy
  • Radio Waves / adverse effects*
  • Spleen / metabolism

Substances

  • Antineoplastic Agents, Alkylating
  • NF-kappa B
  • Cyclophosphamide
  • DNA