Safety assessment of the oral cavity probiotic Streptococcus salivarius K12

Appl Environ Microbiol. 2006 Apr;72(4):3050-3. doi: 10.1128/AEM.72.4.3050-3053.2006.


Streptococcus salivarius is a prominent member of the oral microbiota and has excellent potential for use as a probiotic targeting the oral cavity. In this report we document safety data relating to S. salivarius K12, including assessment of its antibiogram, metabolic profiles, and virulence determinants, and we examine the microbial composition of saliva following the dosing of subjects with K12.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Consumer Product Safety
  • Humans
  • Microbial Sensitivity Tests
  • Mouth / microbiology*
  • Probiotics / administration & dosage*
  • Probiotics / adverse effects*
  • Saliva / microbiology
  • Streptococcus* / drug effects
  • Streptococcus* / metabolism
  • Streptococcus* / pathogenicity


  • Anti-Bacterial Agents