Unearthing uric acid: an ancient factor with recently found significance in renal and cardiovascular disease

Kidney Int. 2006 May;69(10):1722-5. doi: 10.1038/sj.ki.5000391.


Uric acid is strongly associated with cardiovascular and renal disease, but is usually not considered to have a causal role. However, recent experimental, epidemiological, and clinical studies provocatively suggest that uric acid may contribute to the development of hypertension, metabolic syndrome, and kidney disease in some patients. Clinical studies are urgently needed to examine this important possibility.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cardiovascular Diseases / etiology*
  • Humans
  • Kidney Diseases / etiology*
  • Uric Acid / metabolism*


  • Uric Acid