Serous retinal detachment in a patient with aplastic anemia associated with parvovirus B19 infection

Graefes Arch Clin Exp Ophthalmol. 2007 Feb;245(2):324-6. doi: 10.1007/s00417-006-0315-5.


Background: We report a case of unilateral serous retinal detachment (RD) associated with parvovirus B19 infection.

Case report: A 28-year-old woman had a clinical history of autoimmune hemolytic anemia and pure red cell aplasia associated with parvovirus B19 infection. She demonstrated focal serous RD without retinal exudates. A focal cataract and anterior vitreous cells were also observed. Fluorescein angiography (FA) revealed accumulation of subretinal fluid, but no vascular leakage. After vitrectomy, the retina was re-attached and visual acuity returned to 20/20. IgM antibody to parvovirus and viral DNA were detected by polymerase chain reaction in the vitreous fluid obtained at surgery.

Conclusion: To our knowledge, this is the first reported case of the presence of anti-viral IgM and viral DNA in vitreous sample. Furthermore, the ocular findings in our patient are definitively different from previously reported cases of parvovirus-associated ocular disorders.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anemia, Aplastic / diagnosis
  • Anemia, Aplastic / virology*
  • Antibodies, Viral / blood
  • Blood
  • DNA, Viral / analysis
  • Enzyme-Linked Immunosorbent Assay
  • Eye Infections, Viral / complications*
  • Eye Infections, Viral / diagnosis
  • Female
  • Fluorescein Angiography
  • Humans
  • Immunoglobulin M / analysis
  • Parvoviridae Infections / complications*
  • Parvoviridae Infections / diagnosis
  • Parvovirus B19, Human / genetics
  • Parvovirus B19, Human / immunology
  • Parvovirus B19, Human / isolation & purification*
  • Retinal Detachment / diagnosis
  • Retinal Detachment / etiology*
  • Retinal Detachment / surgery
  • Vitrectomy
  • Vitreous Body / virology


  • Antibodies, Viral
  • DNA, Viral
  • Immunoglobulin M