Urinary follicle-stimulating hormone (FSH) is more effective than recombinant FSH in older women in a controlled randomized study

Fertil Steril. 2006 May;85(5):1398-403. doi: 10.1016/j.fertnstert.2005.10.049. Epub 2006 Apr 5.


Objective: The following study was conducted to determine which FSH, recombinant or urinary, works better in older women.

Design: We conducted a controlled randomized study in a single university IVF center.

Setting: University IVF center.

Patient(s): Women (N = 257) over 39 years old undergoing IVF.

Intervention(s): The patients were randomized into two study groups at their first IVF cycle: 121 patients were treated with recombinant FSH, and 120 patients were treated with urinary FSH. Both groups were suppressed with a long GnRH analog protocol.

Main outcome measure(s): Days of stimulation, E2 at the day of hCG, total amount of FSH administered, number of oocytes collected, amount of FSH per oocyte, and number of embryos obtained.

Result(s): Patients treated with urinary FSH required a significantly lower total amount of FSH, and a lower amount of FSH per oocyte than women treated with recombinant FSH. The other measures evaluated did not show any statistically significant differences.

Conclusion(s): Our study showed that urinary FSH performed better in older women than recombinant FSH when associated with the long protocol.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Combined Modality Therapy / statistics & numerical data
  • Female
  • Fertilization in Vitro / statistics & numerical data*
  • Follicle Stimulating Hormone, Human / administration & dosage*
  • Follicle Stimulating Hormone, Human / genetics
  • Humans
  • Incidence
  • Infertility / epidemiology*
  • Infertility / therapy*
  • Italy / epidemiology
  • Pregnancy / statistics & numerical data
  • Pregnancy Outcome / epidemiology*
  • Pregnancy Rate*
  • Recombinant Proteins / administration & dosage
  • Treatment Outcome
  • Urofollitropin / administration & dosage*


  • Follicle Stimulating Hormone, Human
  • Recombinant Proteins
  • Urofollitropin