Effects of Dairy Products Naturally Enriched With cis-9,trans-11 Conjugated Linoleic Acid on the Blood Lipid Profile in Healthy Middle-Aged Men

Am J Clin Nutr. 2006 Apr;83(4):744-53. doi: 10.1093/ajcn/83.4.744.

Abstract

Background: Interest in the development of dairy products naturally enriched in conjugated linoleic acid (CLA) exists. However, feeding regimens that enhance the CLA content of milk also increase concentrations of trans-18:1 fatty acids. The implications for human health are not yet known.

Objective: This study investigated the effects of consuming dairy products naturally enriched in cis-9,trans-11 CLA (and trans-11 18:1) on the blood lipid profile, the atherogenicity of LDL, and markers of inflammation and insulin resistance in healthy middle-aged men.

Design: Healthy middle-aged men (n = 32) consumed ultra-heat-treated milk, butter, and cheese that provided 0.151 g/d (control) or 1.421 g/d (modified) cis-9,trans-11 CLA for 6 wk. This was followed by a 7-wk washout and a crossover to the other treatment.

Results: Consumption of dairy products enriched with cis-9,trans-11 CLA and trans-11 18:1 did not significantly affect body weight, inflammatory markers, insulin, glucose, triacylglycerols, or total, LDL, and HDL cholesterol but resulted in a small increase in the ratio of LDL to HDL cholesterol. The modified dairy products changed LDL fatty acid composition but had no significant effect on LDL particle size or the susceptibility of LDL to oxidation. Overall, increased consumption of full-fat dairy products and naturally derived trans fatty acids did not cause significant changes in cardiovascular disease risk variables, as may be expected on the basis of current health recommendations.

Conclusion: Dairy products naturally enriched with cis-9,trans-11 CLA and trans-11 18:1 do not appear to have a significant effect on the blood lipid profile.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cardiovascular Diseases / blood
  • Cardiovascular Diseases / prevention & control
  • Cholesterol, HDL / blood*
  • Cholesterol, HDL / chemistry
  • Cholesterol, HDL / metabolism
  • Cholesterol, LDL / blood*
  • Cholesterol, LDL / chemistry
  • Cholesterol, LDL / metabolism
  • Cross-Over Studies
  • Dairy Products* / analysis
  • Double-Blind Method
  • Humans
  • Insulin / metabolism
  • Insulin Resistance
  • Isomerism
  • Linoleic Acids, Conjugated / chemistry
  • Linoleic Acids, Conjugated / pharmacology*
  • Lipid Metabolism / drug effects*
  • Male
  • Middle Aged
  • Oxidation-Reduction
  • Risk Factors

Substances

  • Cholesterol, HDL
  • Cholesterol, LDL
  • Insulin
  • Linoleic Acids, Conjugated