Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2006 Apr;83(4):754-9.
doi: 10.1093/ajcn/83.4.754.

Vitamin D Supplementation Improves Cytokine Profiles in Patients With Congestive Heart Failure: A Double-Blind, Randomized, Placebo-Controlled Trial

Affiliations
Randomized Controlled Trial

Vitamin D Supplementation Improves Cytokine Profiles in Patients With Congestive Heart Failure: A Double-Blind, Randomized, Placebo-Controlled Trial

Stefanie S Schleithoff et al. Am J Clin Nutr. .

Abstract

Background: Elevated circulating concentrations of proinflammatory cytokines may contribute to the pathogenesis of congestive heart failure (CHF). In vitro studies suggest that vitamin D suppresses proinflammatory cytokines and increases antiinflammatory cytokines.

Objective: We evaluated the effect of vitamin D supplementation on the survival rate and different biochemical variables in patients with CHF.

Design: One hundred twenty-three patients randomly received either 50 mug vitamin D(3)/d plus 500 mg Ca/d [D(+) group] or placebo plus 500 mg Ca/d [D(-) group] for 9 mo. Biochemical variables were assessed at baseline and after 9 mo. The survival rate was calculated for a follow-up period of 15 mo.

Results: Ninety-three patients completed the study. Significant treatment effects were observed on logarithmic-transformed serum concentrations of 25-hydroxyvitamin D (P = 0.001), parathyroid hormone (P = 0.007), tumor necrosis factor alpha (P = 0.006), and interleukin 10 (P = 0.042). 25-Hydroxyvitamin D increased by 26.8 ng/mL in the D(+) group but increased only by 3.6 ng/mL in the D(-) group. Compared with baseline, parathyroid hormone was significantly lower and the antiinflammatory cytokine interleukin 10 was significantly higher in the D(+) group after 9 mo. The proinflammatory cytokine tumor necrosis factor alpha increased in the D(-) group but remained constant in the D(+) group. The survival rate did not differ significantly between the study groups during the follow-up period.

Conclusions: Vitamin D(3) reduces the inflammatory milieu in CHF patients and might serve as a new antiinflammatory agent for the future treatment of the disease. Our data provide evidence for the involvement of an impaired vitamin D-parathyroid hormone axis in the progression of CHF.

Comment in

  • Vitamin D in congestive heart failure.
    Vieth R, Kimball S. Vieth R, et al. Am J Clin Nutr. 2006 Apr;83(4):731-2. doi: 10.1093/ajcn/83.4.731. Am J Clin Nutr. 2006. PMID: 16600920 No abstract available.

Similar articles

See all similar articles

Cited by 266 articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources

Feedback