Enzymatic gating of voltage-activated calcium channels

Ann N Y Acad Sci. 1991:635:26-34. doi: 10.1111/j.1749-6632.1991.tb36478.x.


The model of calcium-channel gating described above, although almost certainly too simple, suggests a direct role for protein kinases and phosphatases in determining the kinetics of calcium channel gating on a subsecond time scale. In addition, it provides a unique perspective for understanding studies of calcium channel gating under widely different metabolic and pharmacological conditions. Although many of these effects may be specific to the dihydropyridine-sensitive or L-type calcium channel, they give an indication of the range of possibilities for integrating calcium-channel activity with cellular biochemistry.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium Channels / drug effects
  • Calcium Channels / physiology*
  • Dihydropyridines / pharmacology
  • Ion Channel Gating / drug effects
  • Ion Channel Gating / physiology*
  • Phosphoprotein Phosphatases / metabolism
  • Phosphorylation
  • Protein Kinases / metabolism*


  • Calcium Channels
  • Dihydropyridines
  • Protein Kinases
  • Phosphoprotein Phosphatases