Prevalence and clinical predictors of endometrial hyperplasiain anovulatory women presenting with amenorrhea

Gynecol Endocrinol. 2006 Feb;22(2):101-5. doi: 10.1080/09513590600585997.


The aim of the present study was to determine the prevalence and clinical predictors of endometrial hyperplasia (EH) in amenorrheic women with anovulation. Fifty-seven women were enrolled in the study. Of these, 43 were diagnosed to have polycystic ovary syndrome (PCOS) and 14 to have idiopathic anovulation. All women received transvaginal sonography to assess endometrial thickness (ET), patterns and abnormalities. At the same time, an endometrial biopsy was taken using a Pipelle instrument. The women's age, body mass index (BMI) and waist-to-hip ratio (WHR) were 32.0+/-6.0 years, 27.3+/-6.5 kg/m(2) and 0.82+/-0.06 (mean+/-standard deviation), respectively. Twenty (35.1%) and 19 (33.3%) women were classified as obese by BMI and WHR, respectively. Hypertension was found in 17 (29.8%) women. The prevalence of EH was 45.6%. Most cases were simple EH, and only one (1.75%) was simple EH with atypia. EH prevalence was 48.8% and 35.7% in PCOS and idiopathic anovulatory women, respectively. Age, BMI, WHR and ET did not predict EH, whereas the endometrial hyperechogenic pattern was a clinical predictor of EH with borderline significance. In conclusion, this study demonstrated that almost half of the anovulatory women with amenorrhea had EH and no significant predictor was found. In view of these findings, an endometrial biopsy should be performed in all women with this disorder.

MeSH terms

  • Adult
  • Amenorrhea / complications*
  • Anovulation / complications*
  • Biopsy
  • Body Mass Index
  • Endometrial Hyperplasia / diagnosis
  • Endometrial Hyperplasia / epidemiology*
  • Endometrium / diagnostic imaging
  • Endometrium / pathology
  • Female
  • Humans
  • Hypertension / complications
  • Obesity / complications
  • Polycystic Ovary Syndrome / complications
  • Ultrasonography
  • Waist-Hip Ratio