Prenatal exposure to 1,1-dichloro-2,2-bis (p-chlorophenyl)ethylene (p,p'-DDE) in relation to child growth

Int J Epidemiol. 2006 Aug;35(4):853-8. doi: 10.1093/ije/dyl067. Epub 2006 Apr 10.

Abstract

Objective: To examine the relation between prenatal 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) exposure (a metabolite of the insecticide DDT) and child growth during the first 7 years of life. Design Prospective cohort study. Participants 1,712 children born between 1959 and 1966 with measured p,p'-DDE concentrations in their mother's serum samples from pregnancy. Setting Multicenter US Collaborative Perinatal Project (CPP).

Results: The highest prenatal concentrations of p,p'-DDE (>or=60 microg/l), as compared with the lowest (<15 microg/l), were associated with decreased height at age 1 year [adjusted coefficient (SE) = -0.72 cm (0.37), n = 1,540], 4 years [-1.14 cm (0.56), n = 1,289], and 7 years [-2.19 (0.46), n = 1,371]. Among subjects in lower categories of exposure no association was observed.

Conclusions: The findings suggest that high prenatal exposure to p,p'-DDE decreases height in children. Impaired growth may be a general indicator of toxicity and suggests that specific organ systems (e.g. endocrine) could be affected.

Publication types

  • Multicenter Study
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • African Americans
  • Body Height / drug effects
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Dichlorodiphenyl Dichloroethylene / toxicity*
  • Environmental Pollutants / toxicity*
  • European Continental Ancestry Group
  • Female
  • Growth / drug effects*
  • Humans
  • Infant
  • Insecticides / toxicity*
  • Linear Models
  • Male
  • Maternal Exposure
  • Pregnancy
  • Prenatal Exposure Delayed Effects*
  • Prospective Studies
  • Sex Factors

Substances

  • Environmental Pollutants
  • Insecticides
  • Dichlorodiphenyl Dichloroethylene