Organelles on the move: insights from yeast vacuole inheritance

Nat Rev Mol Cell Biol. 2006 Apr;7(4):243-52. doi: 10.1038/nrm1892.


Organelle inheritance is one of several processes that occur during cell division. Recent studies on yeast vacuole inheritance have indicated rules that probably apply to most organelle-inheritance pathways. They have uncovered a molecular mechanism for membrane-cargo transport that is partially conserved from yeast to humans. They have also shown that the transport complex, which is composed of a molecular motor and its receptor, regulates the destination and timing of vacuole movement and might coordinate organelle movement with several other organelle functions.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Cell Cycle / physiology*
  • Models, Biological
  • Models, Molecular
  • Molecular Motor Proteins / physiology
  • Organelles / genetics
  • Organelles / physiology*
  • Saccharomyces cerevisiae Proteins / metabolism
  • Saccharomyces cerevisiae*
  • Vacuoles / genetics
  • Vacuoles / physiology*


  • Molecular Motor Proteins
  • Saccharomyces cerevisiae Proteins