NDR kinases regulate essential cell processes from yeast to humans

Nat Rev Mol Cell Biol. 2006 Apr;7(4):253-64. doi: 10.1038/nrm1891.


Members of the NDR (nuclear Dbf2-related) protein-kinase family are essential components of pathways that control important cellular processes, such as morphological changes, mitotic exit, cytokinesis, cell proliferation and apoptosis. Recent progress has shed light on the mechanisms that underlie the regulation and function of the NDR family members. Combined data from yeast, worms, flies, mice and human cells now highlight the conserved and important roles of the different NDR kinases in distinct cellular processes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Cell Proliferation
  • Gene Expression Regulation, Enzymologic*
  • Humans
  • Mitosis* / physiology
  • Neurons / cytology
  • Neurons / metabolism
  • Protein-Serine-Threonine Kinases / biosynthesis
  • Protein-Serine-Threonine Kinases / chemistry
  • Protein-Serine-Threonine Kinases / physiology*
  • Saccharomyces cerevisiae / enzymology


  • Protein-Serine-Threonine Kinases
  • STK38L protein, human