Sperm guidance in mammals - an unpaved road to the egg

Nat Rev Mol Cell Biol. 2006 Apr;7(4):276-85. doi: 10.1038/nrm1893.


Contrary to the prevalent view, there seems to be no competition in the mammalian female genital tract among large numbers of sperm cells that are racing towards the egg. Instead, small numbers of the ejaculated sperm cells enter the Fallopian tube, and these few must be guided to make the remaining long, obstructed way to the egg. Here, we review the mechanisms by which mammalian sperm cells are guided to the egg.

Publication types

  • Review

MeSH terms

  • Animals
  • Chemotaxis*
  • Female
  • Humans
  • Male
  • Mammals
  • Models, Biological
  • Ovum / physiology*
  • Sperm-Ovum Interactions*
  • Spermatozoa / physiology*
  • Temperature