The role of glutathione in disulphide bond formation and endoplasmic-reticulum-generated oxidative stress

EMBO Rep. 2006 Mar;7(3):271-5. doi: 10.1038/sj.embor.7400645.


Glutathione is a ubiquitous molecule found in all parts of the cell where it fulfils a range of functions from detoxification to protection from oxidative damage. It provides the main redox buffer for cells and as such has been implicated in the formation of native disulphide bonds. However, the discovery of the enzyme Ero1 has called into question the exact role of glutathione in this process. In this review, we discuss the arguments for and against a role for glutathione in facilitating disulphide-bond formation and consider its role in protecting the cell from endoplasmic-reticulum-generated oxidative stress.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Disulfides / metabolism*
  • Endoplasmic Reticulum / metabolism*
  • Glutathione / metabolism*
  • Glycoproteins / metabolism
  • Oxidants / metabolism
  • Oxidation-Reduction
  • Oxidative Stress*
  • Oxidoreductases / metabolism
  • Oxidoreductases Acting on Sulfur Group Donors
  • Reactive Oxygen Species / metabolism
  • Saccharomyces cerevisiae Proteins / metabolism


  • Disulfides
  • Glycoproteins
  • Oxidants
  • Reactive Oxygen Species
  • Saccharomyces cerevisiae Proteins
  • Oxidoreductases
  • Oxidoreductases Acting on Sulfur Group Donors
  • ERO1 protein, S cerevisiae
  • Glutathione