Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects

Nano Lett. 2006 Apr;6(4):669-76. doi: 10.1021/nl052405t.


We report the in vivo targeting and imaging of tumor vasculature using arginine-glycine-aspartic acid (RGD) peptide-labeled quantum dots (QDs). Athymic nude mice bearing subcutaneous U87MG human glioblastoma tumors were administered QD705-RGD intravenously. The tumor fluorescence intensity reached maximum at 6 h postinjection with good contrast. The results reported here open up new perspectives for integrin-targeted near-infrared optical imaging and may aid in cancer detection and management including imaging-guided surgery.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Coated Materials, Biocompatible / analysis
  • Coated Materials, Biocompatible / chemical synthesis
  • Glioblastoma / blood supply*
  • Glioblastoma / metabolism
  • Glioblastoma / pathology*
  • Humans
  • Mice
  • Mice, Nude
  • Microscopy, Fluorescence / methods*
  • Neovascularization, Pathologic / metabolism
  • Neovascularization, Pathologic / pathology*
  • Oligopeptides* / chemistry
  • Oligopeptides* / pharmacokinetics
  • Particle Size
  • Quantum Dots*
  • Spectrophotometry, Infrared / methods*
  • Whole Body Imaging / methods


  • Coated Materials, Biocompatible
  • Oligopeptides
  • arginyl-glycyl-aspartic acid