Anti-inflammatory and antinociceptive activity of flavonoids isolated from Viscum album ssp. album

Z Naturforsch C J Biosci. 2006 Jan-Feb;61(1-2):26-30. doi: 10.1515/znc-2006-1-205.

Abstract

Viscum album L. has been used in the indigenous systems of medicine for treatment of headache and some inflammatory diseases. In order to evaluate this information, antinociceptive and anti-inflammatory activities of the five flavonoids (5,7-dimethoxy naringenin or 4',6'-dimethoxy chalcononaringenin) derivatives, isolated from the ethyl acetate fraction of the extract from V. album ssp. album, were investigated, namely 5,7-dimethoxy-flavanone-4'-O-beta-D-glucopyranoside (1), 2'-hydroxy-4',6'-dimethoxy-chalcone-4-O-beta-D-glucopyranoside (2), 5,7-dimethoxy-flavanone-4'-O-[2"-O-(5"'-O-trans-cinnamoyl)-beta-D-apiofuranosyl]-beta-D-glucopyranoside (3), 2'-hydroxy-4',6'-dimethoxy-chalcone-4-O-[2"-O-(5"'-O-trans-cinnamoyl)-beta-Dapiofuranosyl]-beta-D-glucopyranoside (4), 5,7-dimethoxy-flavanone-4'-O-[beta-D-apiofuranosyl-(1 --> 2)]-beta-D-glucopyranoside (5). For the antinociceptive activity assessment the p-benzoquinone-induced writhing test and for the anti-inflammatory activity the carrageenan-induced hind paw edema model in mice were used. The ethyl acetate fraction in a dose of 250 mg/kg as well as compounds 2 and 5 in a 30 mg/kg dose were shown to possess remarkable antinociceptive and anti-inflammatory activities per os without inducing any apparent acute toxicity as well as gastric damage.

MeSH terms

  • Abdominal Pain / drug therapy
  • Analgesics / isolation & purification*
  • Analgesics / pharmacology
  • Animals
  • Anti-Inflammatory Agents / isolation & purification*
  • Anti-Inflammatory Agents / pharmacology
  • Aspirin / pharmacology
  • Belgium
  • Carrageenan
  • Disease Models, Animal
  • Edema / drug therapy
  • Flavonoids / isolation & purification*
  • Flavonoids / pharmacology
  • Hindlimb
  • Indomethacin / pharmacology
  • Mice
  • Phytotherapy
  • Plant Extracts / isolation & purification*
  • Plant Extracts / pharmacology
  • Plant Leaves / chemistry
  • Plant Stems / chemistry
  • Viscum album / chemistry*

Substances

  • Analgesics
  • Anti-Inflammatory Agents
  • Flavonoids
  • Plant Extracts
  • Carrageenan
  • Aspirin
  • Indomethacin