Abstract
The clinical and histological findings of a 10-year-old girl with virus-associated haemophagocytic syndrome are presented. The serum levels of Epstein-Barr viral antigens were elevated. Epstein-Barr virus (EBV) genome was detected by polymerase chain reaction in bone marrow and lymph node specimens. Histologically, haemophagocytic histiocytes were present in bone marrow, and areas of non-suppurative necrosis were present in lymph nodes, where silver grain deposition of the EBV genome was demonstrated by in situ hybridization.
MeSH terms
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Antigens, Viral / analysis
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Base Sequence
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Bone Marrow / pathology
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Child
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Female
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Ferritins / blood
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Genome, Viral
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Herpesvirus 4, Human* / genetics
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Histiocytes / pathology
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Histiocytosis, Non-Langerhans-Cell / genetics
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Histiocytosis, Non-Langerhans-Cell / immunology
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Histiocytosis, Non-Langerhans-Cell / pathology*
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Humans
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Lymph Nodes / pathology
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Molecular Sequence Data
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Necrosis
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Nucleic Acid Hybridization
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Tumor Virus Infections / genetics
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Tumor Virus Infections / immunology
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Tumor Virus Infections / pathology*
Substances
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Antigens, Viral
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Ferritins