Virus-associated haemophagocytic syndrome with Epstein-Barr virus infection

Virchows Arch A Pathol Anat Histopathol. 1991;419(6):519-22. doi: 10.1007/BF01650682.

Abstract

The clinical and histological findings of a 10-year-old girl with virus-associated haemophagocytic syndrome are presented. The serum levels of Epstein-Barr viral antigens were elevated. Epstein-Barr virus (EBV) genome was detected by polymerase chain reaction in bone marrow and lymph node specimens. Histologically, haemophagocytic histiocytes were present in bone marrow, and areas of non-suppurative necrosis were present in lymph nodes, where silver grain deposition of the EBV genome was demonstrated by in situ hybridization.

Publication types

  • Case Reports

MeSH terms

  • Antigens, Viral / analysis
  • Base Sequence
  • Bone Marrow / pathology
  • Child
  • Female
  • Ferritins / blood
  • Genome, Viral
  • Herpesvirus 4, Human* / genetics
  • Histiocytes / pathology
  • Histiocytosis, Non-Langerhans-Cell / genetics
  • Histiocytosis, Non-Langerhans-Cell / immunology
  • Histiocytosis, Non-Langerhans-Cell / pathology*
  • Humans
  • Lymph Nodes / pathology
  • Molecular Sequence Data
  • Necrosis
  • Nucleic Acid Hybridization
  • Tumor Virus Infections / genetics
  • Tumor Virus Infections / immunology
  • Tumor Virus Infections / pathology*

Substances

  • Antigens, Viral
  • Ferritins