The multifaceted mismatch-repair system

Nat Rev Mol Cell Biol. 2006 May;7(5):335-46. doi: 10.1038/nrm1907.


By removing biosynthetic errors from newly synthesized DNA, mismatch repair (MMR) improves the fidelity of DNA replication by several orders of magnitude. Loss of MMR brings about a mutator phenotype, which causes a predisposition to cancer. But MMR status also affects meiotic and mitotic recombination, DNA-damage signalling, apoptosis and cell-type-specific processes such as class-switch recombination, somatic hypermutation and triplet-repeat expansion. This article reviews our current understanding of this multifaceted DNA-repair system in human cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Base Pair Mismatch / genetics*
  • DNA Repair / genetics*
  • DNA Repair / physiology*
  • Drug Resistance / genetics
  • Exonucleases / metabolism
  • Humans
  • Models, Molecular
  • Proliferating Cell Nuclear Antigen / metabolism


  • Proliferating Cell Nuclear Antigen
  • Exonucleases