Abstract
We report the case of a middle aged Tanzanian man who developed a spinal cord syndrome over 6 weeks, along with a mild encephalopathy. Investigations ruled out the usual major causes of such a syndrome in our setting in northern Tanzania. Examination of his cerebrospinal fluid revealed trypanosomes, and he made a slow but dramatic improvement after a full course of suramine and melarsoprol. We postulate that he had a transverse myelitis due to African trypanosomiasis, a rare and barely recognised cause.
MeSH terms
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Animals
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Developing Countries*
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Drug Therapy, Combination
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Follow-Up Studies
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Humans
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Male
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Melarsoprol / therapeutic use
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Middle Aged
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Myelitis, Transverse / diagnosis
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Myelitis, Transverse / drug therapy
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Myelitis, Transverse / etiology*
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Neurologic Examination / drug effects
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Radiculopathy / diagnosis
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Radiculopathy / drug therapy
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Radiculopathy / etiology
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Spinal Cord Compression / diagnosis
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Spinal Cord Compression / drug therapy
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Spinal Cord Compression / etiology
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Suramin / therapeutic use
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Tanzania
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Trypanocidal Agents / therapeutic use
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Trypanosoma brucei brucei
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Trypanosomiasis, African / complications*
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Trypanosomiasis, African / diagnosis
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Trypanosomiasis, African / drug therapy
Substances
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Trypanocidal Agents
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Suramin
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Melarsoprol