A common genetic variant is associated with adult and childhood obesity

Science. 2006 Apr 14;312(5771):279-83. doi: 10.1126/science.1124779.

Abstract

Obesity is a heritable trait and a risk factor for many common diseases such as type 2 diabetes, heart disease, and hypertension. We used a dense whole-genome scan of DNA samples from the Framingham Heart Study participants to identify a common genetic variant near the INSIG2 gene associated with obesity. We have replicated the finding in four separate samples composed of individuals of Western European ancestry, African Americans, and children. The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • African Americans
  • Alleles
  • Body Mass Index*
  • Case-Control Studies
  • Child
  • Cohort Studies
  • Europe
  • European Continental Ancestry Group
  • Female
  • Gene Frequency
  • Genes, Recessive
  • Genetic Predisposition to Disease
  • Genetic Variation*
  • Genotype
  • Haplotypes
  • Humans
  • Intracellular Signaling Peptides and Proteins / genetics
  • Linkage Disequilibrium
  • Male
  • Membrane Proteins / genetics
  • Models, Genetic
  • Obesity / genetics*
  • Oligonucleotide Array Sequence Analysis
  • Polymorphism, Single Nucleotide*

Substances

  • INSIG2 protein, human
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins