[Cavinton in the prevention of the convulsive syndrome in children after birth injury]

Zh Nevropatol Psikhiatr Im S S Korsakova. 1991;91(8):21-2.
[Article in Russian]


The authors studied the efficacy of cavinton as an agent helpful in preventing neurologic disorders in the newborn with hypoxic ischemic encephalopathy due to intracranial birth trauma. The short-term results of the treatment were elucidated in 61 children. In group I including 20 persons given conventional therapy, the disappearance of seizures was recorded in 6 patients; out of 41 children (group II) given additionally cavinton, in 27. Twenty-nine children were followed up for a year. In group I, convulsive paroxysms recurred in 4 patients, whereas in the group II children, no convulsive syndrome was recorded on the follow-up. The group II children also showed a decrease of the phenomena of intracranial hypertension and normalization of the psychomotor development. The preventive effect of cavinton seen in children with a history of birth trauma may be accounted for by its capacity of normalizing cerebrovascular disorders and by its own anticonvulsive properties.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • English Abstract

MeSH terms

  • Anticonvulsants / administration & dosage*
  • Birth Injuries / complications*
  • Brain Injuries / complications*
  • Humans
  • Infant
  • Infant, Newborn
  • Infusions, Intravenous
  • Seizures / etiology
  • Seizures / prevention & control*
  • Vinca Alkaloids / administration & dosage*


  • Anticonvulsants
  • Vinca Alkaloids
  • vinpocetine