Aleatory clinical study comparing otilonium bromide with a fiber-rich diet in the treatment of irritable bowel syndrome

Ital J Gastroenterol. 1991 Nov;23(8 Suppl 1):67-70.


We studied 114 patients affected by irritable bowel syndrome (IBS) (group A = 53 patients, group B = 61). Group A received diet with high content of roughage (20 g of fibers) and 10 g of bran, group B received otilonium bromide (OB) 40mg tid and normal diet (10-15 g of fibers). Abdominal pain, abdominal distension, bowel movements were evaluated before treatment (T0) at the end (T24) and after 12 months (T12). In group B otilonium bromide induced a significant improvement (p less than 0.01) of abdominal pain and distension when comparing T0 with T24. In group A diet produced an improvement, albeit not significant, of the aforementioned parameters at T24. On the basis of our data OB seems to be more effective than a high-fiber diet in the treatment of IBS.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Abdominal Pain / therapy
  • Adult
  • Colonic Diseases, Functional / therapy*
  • Dietary Fiber / therapeutic use*
  • Evaluation Studies as Topic
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Parasympatholytics / therapeutic use*
  • Quaternary Ammonium Compounds / therapeutic use*
  • Time Factors


  • Dietary Fiber
  • Parasympatholytics
  • Quaternary Ammonium Compounds
  • octylonium