Peutz-Jeghers Syndrome and Management Recommendations

Clin Gastroenterol Hepatol. 2006 Apr;4(4):408-15. doi: 10.1016/j.cgh.2005.11.005.

Abstract

Peutz-Jeghers syndrome (PJS) is an autosomal dominant disease caused by germline mutation of the serine threonine kinase 11 and characterized by hamartomatous polyps in the gastrointestinal tract and mucocutaneous melanin pigmentation. Patients with PJS are at increased risk for common and unusual types of gastrointestinal and nongastrointestinal tumors. This review analyzes currently available literature and describes the clinical characteristics of PJS, assesses the risk of malignancy in this disorder, and delineates management and surveillance recommendations for affected individuals.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Neoplasms / etiology
  • Peutz-Jeghers Syndrome / etiology
  • Peutz-Jeghers Syndrome / pathology*
  • Peutz-Jeghers Syndrome / therapy*
  • Protein-Serine-Threonine Kinases / genetics
  • Risk Factors

Substances

  • STK11 protein, human
  • Protein-Serine-Threonine Kinases