Membrane binding domains

Biochim Biophys Acta. 2006 Aug;1761(8):805-11. doi: 10.1016/j.bbalip.2006.02.020. Epub 2006 Mar 24.


Eukaryotic signaling and trafficking proteins are rich in modular domains that bind cell membranes. These binding events are tightly regulated in space and time. The structural, biochemical, and biophysical mechanisms for targeting have been worked out for many families of membrane binding domains. This review takes a comparative view of seven major classes of membrane binding domains, the C1, C2, PH, FYVE, PX, ENTH, and BAR domains. These domains use a combination of specific headgroup interactions, hydrophobic membrane penetration, electrostatic surface interactions, and shape complementarity to bind to specific subcellular membranes.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Animals
  • Binding Sites / physiology
  • Cell Membrane / metabolism*
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Lipid Metabolism
  • Membrane Lipids / metabolism*
  • Models, Molecular
  • Protein Structure, Tertiary
  • Protein Transport
  • Signal Transduction


  • Membrane Lipids