Effect of pterostilbene on hepatic key enzymes of glucose metabolism in streptozotocin- and nicotinamide-induced diabetic rats

Life Sci. 2006 Jul 10;79(7):641-5. doi: 10.1016/j.lfs.2006.02.036. Epub 2006 Apr 17.

Abstract

The purpose of this study was to investigate the effect of pterostilbene and its effect on key enzymes of glucose metabolism. Diabetic rats were orally administered with pterostilbene (10, 20, 40 mg/kg) for 2, 4 and 6 weeks on glucose was determined. Administration of pterostilbene at 40 mg/kg significantly decreases plasma glucose. Based on these data, the higher dose, 40 mg/kg pterostilbene, was selected for further evaluation. Oral administration of pterostilbene for 6 weeks on glucose, insulin levels and hepatic enzymes in normal and streptozotocin (STZ)-nicotinamide-induced diabetic rats. A significant decrease in glucose and significant increase in plasma insulin levels were observed in normal and diabetic rats treated with pterostilbene. Treatment with pterostilbene resulted in a significant reduction of glycosylated hemoglobin and an increase in total hemoglobin level. The activities of the hepatic enzymes such as hexokinase was significantly increased whereas glucose-6-phosphatase, fructose-1,6-bisphosphatase were significantly decreased by the administration of pterostilbene in diabetic rats. A comparison was made between the action of pterostilbene and the antidiabetic drug--metformin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Glucose / metabolism
  • Diabetes Mellitus / chemically induced*
  • Diabetes Mellitus / metabolism*
  • Diabetes Mellitus, Experimental / metabolism*
  • Dose-Response Relationship, Drug
  • Fructose-Bisphosphatase / blood
  • Glucose / metabolism*
  • Glucose-6-Phosphatase / blood
  • Glycated Hemoglobin A / metabolism
  • Hemoglobins / metabolism
  • Hexokinase / blood
  • Hypoglycemic Agents / pharmacology*
  • Insulin / blood
  • Liver / drug effects*
  • Liver / enzymology*
  • Male
  • Niacinamide*
  • Rats
  • Rats, Wistar
  • Stilbenes / pharmacology*

Substances

  • Blood Glucose
  • Glycated Hemoglobin A
  • Hemoglobins
  • Hypoglycemic Agents
  • Insulin
  • Stilbenes
  • Niacinamide
  • pterostilbene
  • Hexokinase
  • Fructose-Bisphosphatase
  • Glucose-6-Phosphatase
  • Glucose