Production of [15O]water at low-energy proton cyclotrons

Appl Radiat Isot. 2006 Jul;64(7):755-9. doi: 10.1016/j.apradiso.2006.02.096. Epub 2006 Apr 17.


We report a simple system for producing [15O]H2O from 15N in a nitrogen/hydrogen gas target with recycling of the target nitrogen, allowing production on low-energy proton-only accelerators with minimal consumption of isotopically enriched 15N. The radiolabeled water is separated from the target gas and radiolytically produced ammonia by temporary freezing in a small trap at -40 degrees C.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Cyclotrons
  • Isotope Labeling / methods*
  • Nitrogen Isotopes / chemistry
  • Oxygen Radioisotopes / chemistry*
  • Positron-Emission Tomography / methods
  • Water / chemistry


  • Nitrogen Isotopes
  • Oxygen Radioisotopes
  • Water