Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 34 (5 Suppl), S124-31

The Two-Event Model of Transfusion-Related Acute Lung Injury

Affiliations
Review

The Two-Event Model of Transfusion-Related Acute Lung Injury

Christopher C Silliman. Crit Care Med.

Abstract

The objective of this review is to present the two-event model of transfusion-related acute lung injury (TRALI), a life-threatening complication of transfusions that has been the most common cause of transfusion-related death over the past 2 yrs in the United States. The two-event model of TRALI, which is identical to the pathogenesis of the acute respiratory distress syndrome (ARDS), is reviewed and contrasted to antibody-mediated TRALI. Laboratory studies, both in vitro and in vivo, are discussed as well as human studies of TRALI. Methods to avoid patient exposure to blood components that may cause TRALI are also discussed.

Comment in

Similar articles

See all similar articles

Cited by 53 PubMed Central articles

See all "Cited by" articles

Publication types

MeSH terms

Substances

Feedback