[PLAC1/CP1 gene expression and autologous humoral immunity in gastric cancer patients]

Beijing Da Xue Xue Bao Yi Xue Ban. 2006 Apr 18;38(2):124-7.
[Article in Chinese]


Objective: To investigate PLAC1/CP1 as a potential candidate gene in gastric cancer therapy.

Methods: Reverse transcription-polymerase chain reaction (RT-PCR) method was used to detect the expression of PLAC1/CP1 mRNA in gastric cancer tissues and paired adjacent non-cancerous tissues resected from 28 patients with gastric cancer. Specific antibodies against PLAC1/CP1 were also detected by ELISA method in gastric cancer patients.

Results: Fourteen (50%,14/28) out of the 28 gastric cancer samples were PLAC1/CP1 mRNA positive. Of the 28 serum samples tested,eight (29%,8/28) displayed positive seroreactivity against PLAC1/CP1 antigen, accounting for 57% (8/14) of PLAC1/CP1 mRNA positive samples.

Conclusion: PLAC1/CP1 mRNA was expressed in high frequency and induced spontaneous antibody responses in gastric cancer patients. PLAC1/CP1 may be a valuable candidate antigen in gastric cancer immunotherapy.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Neoplasm / immunology
  • Female
  • Gene Expression
  • Humans
  • Immunity, Humoral*
  • Male
  • Pregnancy Proteins / genetics
  • Pregnancy Proteins / metabolism*
  • Stomach Neoplasms / genetics
  • Stomach Neoplasms / immunology*
  • Stomach Neoplasms / metabolism*


  • Antibodies, Neoplasm
  • PLAC1 protein, human
  • Pregnancy Proteins