Multiple paths to multispecificity

Immunity. 2006 Apr;24(4):359-61. doi: 10.1016/j.immuni.2006.03.009.


The limited primary antibody repertoire uses multiple mechanisms to account for the large number of potential antigens. In this issue of Immunity, Sethi et al. (2006) describe a new means for expanding the antibody repertoire, whereby a single antibody isomer binds diverse antigens at different regions of the binding site.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Antibodies / immunology*
  • Antibody Diversity / immunology*
  • Antibody Formation / immunology*
  • Antigen-Antibody Reactions / immunology*
  • Antigens / immunology*
  • B-Lymphocytes / immunology
  • Binding Sites, Antibody / immunology
  • Humans


  • Antibodies
  • Antigens